Proton Magnetic Resonance Spectroscopy along the Pyramidal Tract of Patients with Amyotrophic Lateral Sclerosis

Introduction Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons in the motor cortex, brainstem and spinal cord (pyramidal tract). Previous studies assessed H spectra in different brain areas in patients with ALS [1, 2]. In this work, we have chosen to compare the spectra from different brain regions along the pyramidal tract, and to correlate the data to different clinical manifestations of the disease.